Process efficiency was further increased by identification of optimal method screening sequence, re-definition of the optimal column set and project-specific adaptations considering reduced structural variation of the analytes. Statistical analysis revealed that up to 92% of the tested racemic mixtures could be successfully separated with at least one of the tested conditions of the screening. Using tools such as read. I am at this point unable to get information on the structure of the file type. Screenings were conducted on a test set of 756 racemates that were selected with focus on structural variation and on 2667 proprietary samples from lab routines. rpt Example files are available at.arw file.cdf file.
#CHROMATOGRAM VIEWER OPENLYNX RPT SOFTWARE#
The software searched each MS spectrum to confirm the identification of the compound. To obtain comparable results, you will need to employ a micro-ECD in addition to confirmational dual-columns connected to a 5-meter guard column using a Y Press-Tight connector. For the reduction of chromatogram data into discrete peaks, with a mass spectrum associated to each peak, the LCMS system configurations used either Agilent’s Analytical Studio Reviewer or Waters’s OpenLynx. This process is largely automated and resulted in an efficient and reliable lab process with a minimum requirement for human intervention. This chromatogram was obtained using an Agilent micro-ECD. Proprietary software tools enabled automated method screening of racemates, parallel evaluation of the resulting chromatograms for enantiomer separation and report generation.
We set up an automated screening process to routinely test 10 chiral supercritical fluid chromatography (SFC) methods - five columns combined with two co-solvents - as part of a chiral separation lab workflow. Fast chromatogram viewer 1.